Endocrine Abstracts

Cushing’s disease (CD) is rare in paediatric practice but requires prompt investigation, diagnosis and therapy to prevent longterm complications. We report the case of a young 12-year-old patient who presented with probable Cushing’s disease complicated on the bone level by osteopenia. Cushing’s syndrome seems to have been evolving for 2 years, i.e. at the age of 10, manifesting itself by a weight gain of 20 kg in 18 months. Clinically, she presents clear signs ...

The diagnostic strategy in the face of stunted growth currently leaves an important place for brain imaging, which looks for growth hormone deficiency, a ‘craniopharyngioma’ tumor, or a malformation of the midline or pituitary region. The purpose of our work is to look for abnormalities of the pituitary area in case of stunted growth.Patients and methods: A retrospective descriptive and analytical study involving 69 patients (30 girls/9 boys) w...

Secondary osteoporosis accounts for 10–20% of the causes of osteoporosis in menopausal women. The search for a possible etiology should not be neglected before considering the therapeutic management of any osteoporosis. There is no consensus on the first-line biological tests to be prescribed.Goal: Determine biological abnormalities in postmenopausal women with osteoporosis.Patients/methods: Postmenopausal women are enrolled, ...

Familial hypercholesterolemia (HF) is a rare hereditary dyslipidemia characterized by a major elevation of LDLc, cutaneo-tendinous xanthomas and atheromatous manifestations. This anomaly exposes a high vascular risk, more than 50% for men and 30% for women, occurring early.Observations: We report four cases of HF from the same family, three girls and one boy and whose parents are affected by hypercholesterolemia. The average age of patients is 11 years. ...

Osteoporosis is a worldwide public health problem, particularly in ageing subjectsThe objectives of this study were to screen a sample of postmenopausal women aged >45 years for osteoporosis and to identify its risk factors.Methods: This cross-sectional survey was conducted at the endocrinology department of the Bologhine hospital in Algiers, Algeria. A total of 1062 postmenopausal women participated in this study. Each subject...

Diabetes mellitus and osteoporosis are important comorbidities commonly seen in postmenopausal women. Diabetes can cause bone alterations that increases the risk of fractures. However, in patients with type 2 diabetes, bone mineral density (BMD) often appears not to be decreased, due to diabetes-induced increased weight and body fat mass, which can hamper densitometric assessment of osteoporosis and of fracture risks. The aim of the present study was to compare bone mineral de...

Introduction: Pathologies of the pituitary stem are very often revealed during diabetes insipidus. The introduction of MRI constituted, in this context, a major diagnostic contribution. We report 4 cases of thickening of the pituitary stem observations. These are 4 patients (3 women and one man) whose age varies from 30 to 47 years, the circumstances of discovery are represented by amenorrhea in women and polyuropolydipsic syndrome in men. Clinically, diabetes insipidus was fo...

The craniopharyngioma is a benign tumor, curable but aggressive by its localization involving the vital and visual prognosis of the patients. Treated mainly by surgery associated with radiotherapy which allows high long-term survival but at the expense of significant side effects, it nevertheless poses a problem of therapeutic management. The aim of this study is to illustrate the therapeutic difficulties in the management of craniopharyngiomaPatients an...

Introduction: Pituitary apoplexy is a rare and potentially life-threatening endocrine and neurosurgical emergency, most often linked to hemorrhage or necrosis of a pituitary adenoma.Observation: We report the case of a 45 year old patient, with a history of chronic headache, hospitalized in the emergency setting for the management of meningeal syndrome with severe headache associated with vomiting, a significant drop in visual acuity, exophthalmos and pt...

IntroductionThe diagnosis of primary hyperparathyroidism (PHP) is essentially biological. Current imaging techniques (ultrasound and scintigraphy) make it possible to locate an adenoma in the majority of cases. The objective of this study is to clarify the place of imaging in the topographic diagnosis of hyperparathyroidism.Patients and methodsThis is a retrospective study including 40 patients with PHP who h...